USP 98% Coenzyme Q10

Product Name: Coenzyme Q10 CAS #: 303-98-0 Molecular formula: C59H90O4 Molucular weight: 863.34 Product Name: Coenzyme Q10CAS #:   303-98-0Molecular formula: C59H90O4Molucular weight: 863.34Synonyms: Ubiquinone-10, CoQ10, Ubiquinone 50, UbidecarenoneFormulation:     Yellow to orange crystalline powderPurity: 98.0-101.0% (USP28)    Application/Function: Coenzyme Q10 (also known as ubiquinone, ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10, CoQ, Q10, or simply Q) is a 1,4-benzoquinone, where Q refers to the quinone chemical group, and 10 refers to the isoprenyl chemical subunits.This vitamin-like substance is present in most eukaryotic cells, primarily in the mitochondria. It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. Ninety-five percent of the human body’s energy is generated this way.Therefore, those organs with the highest energy requirements—such as the heart and the liver—have the highest CoQ10 concentrations.Biochemical roleCoQ is found in the membranes of many organelles. Since its primary function in cells is in generating energy, the highest concentration is found on the inner membrane of the mitochondrion. Some other organelles that contain CoQ10 include endoplasmic reticulum, peroxisomes, lysosomes, and vesicles.SupplementationBecause of its ability to transfer electrons and therefore act as an antioxidant, Coenzyme Q is used as a dietary supplement.According to the Mayo Clinic "CoQ10 has been used, recommended, or studied for numerous conditions, but remains controversial as a treatment in many areas." Further clinical results are needed to determine whether the supplementation with Coenzyme Q10 is beneficial for healthy people.Mitochondrial disordersSupplementation of Coenzyme Q10 is a treatment for some of the very rare and serious mitochondrial disorders and other metabolic disorders, where patients are not capable of producing enough coenzyme Q10 because of their disorder. Coenzyme Q10 is then prescribed by a physician.Heart failureThere is some clinical evidence that supplementation with Coenzyme Q10 is beneficial treatment of patients with congestive heart failure. However, The American College of Cardiology recently published an expert consensus document concluding that the value of coenzyme Q10 in cardiovascular disease has not been clearly established. The Mayo clinic says that there is not enough scientific evidence to recommend for or against the use of CoQ10 in patients with coronary heart disease.Migraine headachesSupplementation of Coenzyme Q10 has been found to have a beneficial effect on the condition of some sufferers of migraine headaches. So far, three studies have been done, of which two were small, did not have a placebo group, were not randomized, and were open-label, and one was a double-blind, randomized, placebo-controlled trial, which found statistically significant results despite its small sample size of 42 patients. Dosages were 150 to 300 mg/day.CancerIt is also being investigated as a treatment for cancer, and as relief from cancer treatment side-effects.Cardiac arrestAnother recent study shows a survival benefit after cardiac arrest if coenzyme Q10 is administered in addition to commencing active cooling (to 32–34 degrees Celsius).Blood pressureThere are several reports concerning the effect of CoQ10 on blood pressure in human studies. In a recent meta-analysis of the clinical trials of CoQ10 for hypertension, a research group led by Professor Frank Rosenfeldt (Director, Cardiac Surgical Research Unit, Alfred Hospital, Melbourne, Australia) reviewed all published trials of Coenzyme Q10 for hypertension, and assessed overall efficacy, consistency of therapeutic action, and side-effect incidence. Meta-analysis was performed in 12 clinical trials (362 patients) comprising three randomized controlled trials, one crossover study, and eight open-label studies. The research group concluded that coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side-effects.

USP 98% Coenzyme Q10